- Title
- Interleukin-13 regulates secretion of the tumor growth factor-β superfamily cytokine activin A in allergic airway inflammation
- Creator
- Hardy, Charles L.; LeMasurier, Jeanne S.; O'Hehir, Robyn E.; Olsson, Fredrik; Dang, Thanh; Yao, Jun; Yang, Ming; Plebanski, Magdalena; Phillips, David J.; Mollard, Richard; Rolland, Jennifer M.
- Relation
- American Journal of Respiratory Cell and Molecular Biology Vol. 42, Issue 6, p. 667-675
- Publisher Link
- http://dx.doi.org/10.1165/rcmb.2008-0429OC
- Publisher
- American Thoracic Society
- Resource Type
- journal article
- Date
- 2010
- Description
- Activin A is a member of the TGF-β superfamily and plays a role in allergic inflammation and asthma pathogenesis. Recent evidence suggests that activin A regulates proinflammatory cytokine production and is regulated by inflammatory mediators. In a murine model of acute allergic airway inflammation,we observed previously that increased activin A concentrations in bronchoalveolar lavage (BAL) fluid coincide with Th2 cytokine production in lung-draining lymph nodes and pronounced mucus metaplasia in bronchial epithelium. We therefore hypothesized that IL-13, the key cytokine for mucus production, regulates activin A secretion into BAL fluid in experimental asthma. IL-13 increased BAL fluid activin A concentrations in naive mice and dose dependently induced activin A secretion from cultured human airway epithelium. A key role for IL-13 in the secretion of activin A into the BAL fluid during allergic airway inflammation was confirmedin IL-13–deficient mice. Eosinophilswere not involved in this response because there was no difference in BAL fluid activin A concentrations between wild-type and eosinophildeficient mice. Our data highlight an important role for IL-13 in the regulation of activin A intraepithelially and in BAL fluid in naive mice and during allergic airway inflammation. Given the immunomodulatory and fibrogenic effects of activin A, our findings suggest an important role for IL-13 regulation of activin A in asthma pathogenesis
- Subject
- activin A; IL-13; inflammation; lung; knockout mice
- Identifier
- http://hdl.handle.net/1959.13/931586
- Identifier
- uon:11110
- Identifier
- ISSN:1044-1549
- Language
- eng
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